Bedaquiline is an anti-tuberculosis drug.
Bedaquiline's unique and specific anti-mycobacterial activity derives from inhibition of the proton pump of mycobacterial ATP synthase, which is a critical enzyme in the ATP synthesis of M. tuberculosis. Binding of bedaquiline to the oligomeric and proteolipic subunit-c of mycobacterial ATP synthase leads to inhibition of ATP synthesis, which subsequently results in bacterial death.
MW: 555.5 g/mol
CAS Number: 843663-66-1