GW-7647
GW-7647 is a potent, selective agonist of human and murine PPARα.
It activates human PPARα, PPARγ, and PPARδ with EC₅₀ values of 0.006, 1.1 and 6.2 µM, respectively, in a GAL4-PPAR binding assay. Similar EC₅₀ values of 0.001, 1.3, and 2.9 were observed with the murine receptors.
Modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro. Has lipid-lowering effects following oral administrationin vivo. Reduces NO production in macrophages; exhibits anti-inflammatory properties.
Formula:
C₂₉H₄₆N₂O₃S MW: 502.75 g/mol |
MDL Number:
MFCD06798379 CAS Number: 265129-71-3 UN: 3316 |
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