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CCG-1423

Supplier: BioVision

Synonyms: N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide , N-((1-((4-Chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide

AB229181-25MG AB229181-5MG

75836-870EA 244.76 USD

75836-870 75836-872

CCG-1423

CCG-1423

CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription.

CCG-1423 displays activity in several in vitro cancer cell functional assays. CCG-1423 potently (<1 mumol/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, and whereas it inhibits the growth of RhoC-overexpressing melanoma lines at nanomolar concentrations, it is less active on related lines that express lower levels of Rho. Similarly, CCG-1423 selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell line (A375M2) compared with the parental cell line (A375).

Formula: C₁₈H₁₃ClF₆N₂O₃
MW: 454.8 g/mol

MDL Number: MFCD01566719
CAS Number: 285986-88-1
UN: 3316

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