BAY 41-2272
Synonyms:
5-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine
BAY 41-2272 is a soluble guanylyl cyclase (sGC) activator; acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit.
Inhibits platelet aggregation (IC₅₀ = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC₅₀ = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.
Formula:
C₂₀H₁₇FN₆ MW: 360.3876 g/mol |
MDL Number:
MFCD06411391 CAS Number: 256376-24-6 UN: 3316 |
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