Dextromethorphan hydrobromide monohydrate

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Dextromethorphan hydrobromide monohydrate
Dextromethorphan hydrobromide monohydrate

Dextromethorphan (DXM) is a morphinan with structural similarity to levorphanol, codeine, and morphine.


DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM).


It is a Cytochrome P450 2D6 substrate and it is converted into the active metabolite dextrorphan in the liver

Formula: C₁₈H₂₅NO·HBr·H₂O
MDL Number: MFCD02173901
CAS Number: 6700-34-1
UN: 3316

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