Human Peripheral Blood CD3 Pan T Cells, Charles River Laboratories Cell Solutions

Supplier: Charles River Laboratories Cell Solutions

PB03C-4

103051-088EA 3122.31 USD

103051-088

Human Peripheral Blood CD3 Pan T Cells, Charles River Laboratories Cell Solutions

Cells

CD3 T cells are isolated from a LeukoPak collected from IRB-consented volunteer donors.

Isolated from mononuclear cells by positive selection
Negative selection is also available
Immunomagnetic cell separation procedures

The CD3+ T cell possesses a complex of cell surface molecules that associates with the T-cell antigen receptor (TCR)

CD3+ T Cells are isolated from mononuclear cells by positive selection using immunomagnetic cell separation procedures. Negative selection is also available at your request.

CD3 functions in the cell surface expression of TCR and in the signaling transduction cascade that originates when a peptide: MHC ligand binds to the TCR. CD3 surface protein is made of invariant subchains belonging to the immunoglobulin superfamily. CD3 is found on the surfaces of T cells and of thymocytes. Mutant expression of the TCR can be found in Severe Combined Immunodeficiency (SCID), and monoclonal antibodies to the CD3 marker have been demonstrated to be an effective way to control allografts by preventing T-cell activation.

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