Anti-CD86 Rat Monoclonal Antibody (PE-Cyanine7) [clone: GL-1 (GL1)]

Supplier: Tonbo Biosciences
60-0862-U100 60-0862-U025
75834-282EA 128.36 USD
75834-282 75834-284
Anti-CD86 Rat Monoclonal Antibody (PE-Cyanine7) [clone: GL-1 (GL1)]
The GL-1 antibody reacts with mouse CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The GL-1 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells.

Type: Primary
Antigen: CD86 (B7-2)
Clonality: Monoclonal
Clone: GL-1 (GL1)
Conjugation: PE-Cyanine7
Host: Rat
Isotype: Rat IgG2a, kappa
Reactivity: Mouse
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