Anti-CD3e Armenian Hamster Antibody (APC-Cyanine7) [clone: 145-2C11]

Supplier: Tonbo Biosciences
25-0031-U100 25-0031-U025
75834-320EA 143.96 USD
75834-320 75834-322
Anti-CD3e Armenian Hamster Antibody (APC-Cyanine7) [clone: 145-2C11]
The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 145-2C11 antibody is a widely used phenotypic marker for mouse T cells. In addition, binding of 145-2C11 antibody to CD3e can induce cell activation. A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. J. Biol. Chem. 287: 13324-13335).

Type: Primary
Antigen: CD3e
Clone: 145-2C11
Conjugation: APC-Cyanine7
Host: Armenian Hamster
Isotype: Armenian Hamster IgG
Reactivity: Mouse
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