Human Marrow Stromal Cells (HMSC) are isolated from fetal human bone marrow.
- Can be cultured and propagated for 10 population doublings
- Can be induced to differentiate into cells of different connective tissue lineage, such as bone, cartilage, and fat
- HMSCs are capable of cell fates crossing germ layer boundaries
Human Marrow Stromal Cells (HMSC) are isolated from fetal human bone marrow. They are cryopreserved at second passage and can be cultured and propagated for 10 population doublings. In addition to supporting hematopoietic cells, marrow stromal cells can be induced to differentiate into cells of different connective tissue lineage, such as bone, cartilage, and fat. The potential of HMSCs to maintain multipotency and proliferate extensively in vitro provides new avenues for cell-based therapy in the restoration of damaged or diseased tissue. Recent reports indicate that HMSCs are capable of cell fates crossing germ layer boundaries. In addition to differentiating into multi-lineages of the mesoderm, these cells can also differentiate into neurons of ectodermal origin and hepatocyte-like cells of endodermal origin.