sE-Selectin Monkey ELISA, BioVendor

Supplier: BioVendor
RAF099R
102552-208EA 1015.54 USD
102552-208
sE-Selectin Monkey ELISA, BioVendor
Assays ELISAs
Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1, E-selectin) belongs to the selectin family of adhesion molecules.

  • Calibration Range: 0.94-60 U/mL
  • Limit of Detection: 0.39 U/mL
  • Baboon serum: 20 uL/well

Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1, E-selectin) belongs to the selectin family of adhesion molecules. Together with LECAM-1 (L-selectin) and GMP-140 (P-selectin), E-selectin mediates the initial interactions of leukocytes and platelets with endothelial cells. Molecular structure: The extracellular part of all selectins consists of an aminoterminal c-type lectin domain which specifically binds to carbohydrate ligands. This is followed by an EGF-like domain, and, in the case of E-selectin, by 6 short consensus repeats. The transmembrane portion of the molecule is followed by a short cytoplasmic tail. Selectins guide non-activated polymorphonuclear cells to the areas of inflammation in creating first, loose contacts with the endothelial layer. The potential binding partner of E-selectin contains sialyl LewisX oligosaccharide. Other suitable ligands for the lectin domain of Eselectin are sialylated, fucosylated lactosaminoglycans. Together with GMP-140, E-selectin is expressed on cytokine-activated endothelial cells, and contributes to the adhesion of still resting leukocytes to the endothelium. This initial binding event is an essential prerequisite for the activation of the immune cells via different inflammatory mediators. In contrast to GMP-140, E-selectin is maximally expressed 2–4 hours after cell activation. Within the next 24–48 hours E-selectin is again eliminated from the cytoplasmic membrane by shedding into the circulation. The circulating form or soluble (sE-selectin) of this selectin exerts chemotactical signals on neutrophils and additionally activates the 2-integrins – sE-selectin assists in preparing the migration capacity of these cells. Determination of monkey sE-selectin could provide more detailed insights into the pathological modifications during various diseases.

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.
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