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Bovine Fibrinogen 90% CLOTTABLE, MP Biomedicals

Supplier: MP BIOMEDICALS (FKA ICN BIOMED
08820226
Bovine fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP). It can be used for preparation of fibrin plates for analysis of fibrinolytic enzymes, a substrate for clotting assays, and study of fibrinogen degradation products.

Since fibrinogen is very similar among species, correspondingly similar characteristics would be expected for bovine, cat, dog, guinea pig, human, sheep, mouse, and rat fibrinogens. In general, fibrinogen from any mammalian source will cross-react with thrombin from any mammalian source. When any mammalian thrombin is injected into a different mammal, clotting will occur.

Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.

Clottable Protein: > 90%; Country of Origin: New Zealand; Excipients : Trisodium Citrate, NaCl, Tween 80; Moisture content: 0.022




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
50 g 08820226 10273-304 Each (50g) Retrieving

Temperature sensitive This Item is temperature sensitive and has specific temperature and storage requirements for shipping/delivery. Shipping duration cannot exceed 2 days.

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SPECIFICATIONS

Protein/Peptide Name Fibrinogen
Protein Synonyms Factor IFibrinogen
Protein/Peptide Type Native
Species Bovine
Source Plasma
CAS No. 9001-32-5
Grade Diagnostic Grade
Purity Protein: 70% w/w
Molecular Weight 63.5 kDa
Formulation Powder, pH 6.4 (1% w/v in saline )
Color White
Tested Applications Substrate for clotting assays
Solubility Soluble in saline. Clear to slightly, hazy solution.
Protein Type Native
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