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Recombinant Human BDNF, MP Biomedicals

Supplier: MP BIOMEDICALS (FKA ICN BIOMED
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
2 µg 08P983611 10496-932 Each (2µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name BDNF
Protein Synonyms Brain Derived Neurotrophic Factor
Protein/Peptide Type Recombinant
Species Human
Source E. coli
Sequence MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Endotoxin Content 0.1 ng/µg of protein (1EU/µg)
Protein Type Recombinant
Specific Activity Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 µg/mL.
Reactivity Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat
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