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Recombinant Human BMP-7, MP Biomedicals

Supplier: MP BIOMEDICALS (FKA ICN BIOMED
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potent bone inducing agent, which in the presence of appropriate osteoconductive carrier (e.g. collagen sponge or synthetic hydroxyapatite) can be used in the treatment of bone defects. A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derived collagen, has recently been approved by the FDA as a device for treating critical-size bone fractures. The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation. Recombinant human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 315 to 431 of the full-length BMP-7 precursor.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
2 µg 08P983731 10496-938 Each (2µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name BMP7
Protein Synonyms OP-1
Protein/Peptide Type Recombinant
Species Human
Source CHO cells
Sequence MANVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG ECAFPLNSYM NATNHAIVQT LVHFINPETV PKPCCAPTQL NAISVLYFDD SSNVILKKYR NMVVRACGCH
Endotoxin Content <0.1 ng/µg of protein (<1EU/µg)
Protein Type Recombinant
Specific Activity Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.02-0.04 µg/mL.
Reactivity Mouse
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