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Tim-3 Recombinant Protein, Prosci

Supplier: Prosci
90-550
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

This recombinant proteins is for research use only.

Fusion-Tag: Fc Tag




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μg 90-550 75794-566 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Protein/Peptide Name TIM3
Protein Synonyms HAVcr-2, T Cell Immunoglobulin and Mucin Domain-containing Protein 3, Hepatitis A Virus Cellular Receptor 2, TIMD3, TIM3
Protein/Peptide Type Recombinant
Species Mouse
Source CHO cells
Sequence 21-189
Purity >98% (SDS-PAGE)
Formulation Lyophilized from 0.2um-filtered solution in PBS.
Biological Activity Immobilized recombinant human Galectin-9 at 500ng/ml can bind Tim-3 (mouse):Fc (human) (rec.) with an apparent KD <10nM. Optimal dilutions should be determined by each laboratory for each application.
Storage Conditions Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
Protein Type Recombinant
Modification Fc Tag
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