Mouse Recombinant GITRL (soluble) (from HEK293 cells)

Supplier: ProSci
90-004
75793-514EA 734.28 USD
75793-514
Mouse Recombinant GITRL (soluble) (from HEK293 cells)
Proteins and Peptides
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

  • Fusion-Tag: DDDDK Tag

This recombinant proteins is for research use only.
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