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EpCAM Recombinant Protein, Prosci

Supplier: Prosci
91-314
Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein that belongs to the EPCAM family. EpCAM is composed of an extracellular domain with one thyroglobulin type-1 domain, a transmembrane domain and a cytoplasmic domain. EpCAM is found on the surface of adenocarcinoma, but not on mesodermal or neural cell membranes. The EpCAM molecule has been shown to function as a homophilic Ca2+ independent adhesion molecule. It may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium as an immunological barrier providing the first line of defense against infection. Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8 (HNPCC8) and diarrhea type 5 (DIAR5). EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells.

This recombinant protein can be used for biological assays. For research use only.

Fusion-Tag: C-6 His tag




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.05 mg 91-314 75789-304 Each (50µG) Retrieving

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Protein/Peptide Name EPCAM
Protein Synonyms Epithelial Cell Surface Antigen, GA733-2, EGP314, M4S1, Epithelial Glycoprotein 314, Adenocarcinoma-Associated Antigen, Epithelial Cell Adhesion Molecule, Ep-CAM, TROP1, MIC18, KS 1/4 Antigen, Major Gastrointestinal Tumor-Associated Protein GA733-2, hEGP314, TACSTD1, CD326, EGP, KSA, EPCAM, Cell Surface Glycoprotein Trop-1, M1S2, Tumor-Associated Calcium Signal Transducer 1, Epithelial Glycoprotein
Protein/Peptide Type Recombinant
Species Human
Source Cells
Sequence Gln24-Lys265
Purity > 95% as determined by reducing SDS-PAGE
Endotoxin Content <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Molecular Weight 28.43 kD
Formulation Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage Conditions Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
Tested Applications For Biological Assays
Protein Type Recombinant
Modification C-6 His tag
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