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CXCL4 Recombinant Protein, Prosci

Supplier: Prosci
Human Chemokine (C-X-C motif) Ligand 4 (CXCL4) is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4 contains several heparin-binding sites at the C-terminal region and binds heparin with high affinity. The active CXCL4 protein is a tetramer. Human and mouse CXCL4 share 64% sequence identity. CXCL4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair. CXCL4 functions via a splice variant of the chemokine receptor CXCR3, known as CXCR3B. The major physiologic role of CXCL4 appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. In contrast to other CXC chemokines, CXCL4 lacks chemotactic activity for polymorphonuclear granulocytes.

This recombinant protein can be used for biological assays. For research use only.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.05 mg 91-044 75788-812 Each (50µG) Retrieving

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Protein/Peptide Name CXCL4
Protein Synonyms Oncostatin-A, Iroplact, PF4, Platelet Factor 4, C-X-C Motif Chemokine 4, PF-4, SCYB4, CXCL4
Protein/Peptide Type Recombinant
Species Human
Source E. coli
Sequence Glu32-Ser101
Purity > 95% as determined by reducing SDS-PAGE
Endotoxin Content <0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Molecular Weight 7.8 kD
Formulation Lyophilized from a 0.2 um filtered solution of 50mM TrisHCl, 150mM NaCl, pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Biological Activity ED50 is 5-15 μg/mL as determined by the ability of Recombinant CXCL4 to inhibit human FGF basic dependent proliferation of NR6R3T3 mouse fibroblasts.
Storage Conditions Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
Tested Applications Bioassay
Protein Type Recombinant
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