Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).
Flow Cytometry: (1:20-1:100). Optimal conditions should be determined individually for each application.
Type: Primary
Antigen: JAG1
Clonality: Monoclonal
Clone: J1G53-3
Conjugation: FITC
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human