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Human recombinant pro urokinase (from E. coli)

Supplier: BioVision

Fig 1 : SDS-PAGE (12%) of Activation of h-Pro-Urokinase: 1: Protein Marker 2: Pro-Urokinase (15 ?g) 3-4: Pro-Urokinase (15 ?g) after 2 h and 3 h of activation with Plasmin respectively. Fig 2: Activity of Pro-Urokinase measured after activation with plasmin using Urokinase Activity Assay Kit

Fig 1 : SDS-PAGE (12%) of Activation of h-Pro-Urokinase: 1: Protein Marker 2: Pro-Urokinase (15 ?g) 3-4: Pro-Urokinase (15 ?g) after 2 h and 3 h of activation with Plasmin respectively. Fig 2: Activity of Pro-Urokinase measured after activation with plasmin using Urokinase Activity Assay Kit

AB285954-500UG AB285954-50UG AB285954-10UG

10834-830EA 2413.18 USD

10834-830 10834-828 10834-826

Human recombinant pro urokinase (from E. coli)

Enzymes

>9% Pure Recombinant human Pro-Urokinase

The enzyme is fully active as seen from its ability to cleave a fluorogenic substrate N-carbobenzyloxy-Gly-Gly-Arg-7-amido-4-methylcoumarin (Z-GGR-AMC) (Cat # K728-100).

Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys157 and Ile158. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.

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