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CellExp™ Human Recombinant Sdll-4 (from HEK293 Cells)

Supplier: BioVision

CellExp™ Human Recombinant Sdll-4 (from HEK293 Cells)

CellExp™ Human Recombinant Sdll-4 (from HEK293 Cells)

CellExp™

7134-50 7134-10

10009-198EA 671.3 USD

10009-198 10009-196

CellExp™ Human Recombinant Sdll-4 (from HEK293 Cells)

>95% Pure active Human Recombinant Human expressed sDLL-4.

The sDLL-4, when immobilized at concentrations > 1.5 μg/mL will inhibit myogenesis in C2C12 cells.

Human sDLL4 comprises the extracellular signaling domain of DLL, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. DLL4 functions to specifically activate the Notch-1 and Notch-4 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Targeted deletion of the DLL4 gene in mice resulted in severe vascular defects and death before birth. Up-regulation of DLL4 expression has been implicated in the vascular development of certain tumors. Recombinant human sDLL4 is a 54.3 kDa glycoprotein containing 498 amino-acid residues.

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