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Human CellExp™ DKK-1, Human Recombinant, BioVision

Supplier: BioVision
>97% Pure active Human Recombinant Human expressed DKK-1.

Determined by its ability to inhibit the proliferation of HCT116 colorectal carcinoma cells. Approximately 40% growth inhibition was achieved at a DKK-1 concentration of 200 ng/ml.

DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β catenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β catenin signaling cascade. It has been suggested that by inhibiting Wnt/β catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. Recombinant human DKK-1 expressed in human 293 cells is a 35-40 kDa glycoprotein containing 235 amino-acid residues.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 μg 7132-10 10009-188 Each (10µG) Retrieving Restricted
50 μg 7132-50 10009-190 Each (50µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name DKK1
Protein Synonyms Dickkopf-1, SK, Dickkopf-related protein-1 Dickkopf-related protein-1, Dickkopf-1, SK
Protein/Peptide Type Recombinant
Species Human
Source HEK293 cells
Purity ≥97%
Endotoxin Content < 0.1 ng/μg of protein (<1EU/μg).
Molecular Weight 35-40 kDa
Formulation Sterile filtered through a 0.2 micron filter. Lyophilized from 1X PBS, pH 7.5.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Protein Type Recombinant
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