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sCD100/Semaphorin-4D, Human Recombinant, BioVision

Supplier: BioVision
>97% Pure active Human Recombinant sCD100.

Measured by its ability to inhibit chemokine (hMCP-3) induced human monocyte migration.

The Semaphorins are a large family of phylogenetically conserved proteins that play a pivotal role in maintaining homeostasis in the immune system. Twenty members of this family have been identified and categorized into eight subclasses based on sequence similarity and distinctive structural features. CD100, also known as Sema4D, is a 150 kDa transmembrane class IV semaphorin. Studies have shown that CD100 can induce monocyte migration, T-cell activation, and B-cell survival, as well as T/B cell and T/DC “cooperation”. The CD100 precursor contains 862 amino acids, including a 21 aa. signal sequence, a 713 aa. extracellular domain, a 21 aa transmembrane sequence, and a 107 aa cytoplasmic region. The extracellular sequence contains several structural features, including a 479 aa “sema” domain, a 79 aa. Ig-like sequence, and a 52 aa “Plexin-type repeat”. Recombinant soluble CD100 is a 78.9 kDa protein comprising the extracellular domain of CD100 (711 amino acids). SDS-PAGE analysis run under non-reducing conditions shows a mixture of disulfide linked dimer and monomer.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 μg 7126-10 10009-164 Each (10µG) Retrieving Restricted
50 μg 7126-50 10009-166 Each (50µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name Scd100
Protein Synonyms Semaphorin 4D
Protein/Peptide Type Recombinant
Species Human
Source CHO cells
Purity ≥97%
Endotoxin Content < 0.1 ng/μg of protein (<1EU/μg).
Molecular Weight 78.9 kDa
Formulation Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Protein Type Recombinant
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