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sCD27 Ligand, Human Recombinant, BioVision

Supplier: BioVision
>95% Pure active Human Recombinant sCD27.

Determined by its ability to stimulate human IL-8 production by human PBMC using a concentration range of 10.0-25.0 ng/ml. Note: Results may vary with PBMC donors.

CD27 Ligand, a type II transmembrane protein, is a member of the TNF superfamily. It is expressed on activated T and B lymphocytes as well as NK cells. CD27L and its receptor (CD27) regulate the immune response by promoting T-cell expansion and differentiation, as well as NK enhancement. CD27 signaling can act as a co-stimulatory effector to sustain the survival of CD8+ T cells, primarily by inducing increased expression of the IL-2 gene. Full length human CD27L is a 193 amino acid protein, consisting of a 17 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 155 amino acid extracellular domain. Human soluble CD27L corresponds to the 155 amino acid extracellular domain of the full length CD27L protein. BioVision’s recombinant human sCD27L contains the extracellular domain plus an N-terminal His-Tag.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 μg 7125-10 10009-160 Each (10µG) Retrieving Restricted
50 μg 7125-50 10009-162 Each (50µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name SCD27 Ligand
Protein Synonyms CD70, TNFSF7 TNFSF7, CD70
Protein/Peptide Type Recombinant
Species Human
Source CHO cells
Purity ≥95%
Endotoxin Content < 0.1 ng/μg of protein (<1EU/μg).
Molecular Weight 19.2 kDa
Formulation Sterile filtered through a 0.2 micron filter. Lyophilized from 20 mM Sodium Citrate, pH 3.0.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Protein Type Recombinant
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