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APRIL, Mouse Recombinant, BioVision

Supplier: BioVision
>95% Pure active Murine Recombinant APRIL.

Determined by its ability to induce cell proliferation of activated T-cells.

APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant murine APRIL is a soluble 21.9 kDa protein, consisting of 192 amino acid residues.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 μg 7118-10 10009-132 Each (10µG) Retrieving Restricted
50 μg 7118-50 10009-134 Each (50µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name April APRIL
Protein Synonyms A Proliferating-inducing Ligand
Protein/Peptide Type Recombinant
Species Mouse
Source E. coli
Purity ≥95%
Endotoxin Content < 0.1 ng/μg of protein (<1EU/μg).
Molecular Weight 21.9 kDa
Formulation Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 5 and 100 mM Arginine.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-0.5 mg/ml.
Protein Type Recombinant
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