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Amphiregulin, Human Recombinant, BioVision

Supplier: BioVision
>95% Pure active Human Recombinant Amphiregulin.

Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells.
The expected ED50 for this effect is 5-10 ng/ml.

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-a receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant human Amphiregulin is a 11.3 kDa glycoprotein consisting of 98 amino acid residues.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 μg 7114-10 10009-116 Each (10µG) Retrieving Restricted
50 μg 7114-50 10009-118 Each (50µG) Retrieving Restricted
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* Please note if your account is within the State of California two of these pieces of identification will be required.
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SPECIFICATIONS

Protein/Peptide Name Amphiregulin
Protein Synonyms AR, CRDGF, Colorectum cell-derived growth factor, AREG Colorectum cell-derived growth factor, AR, AREG, CRDGF
Protein/Peptide Type Recombinant
Species Human
Source E. coli
Purity ≥95%
Endotoxin Content < 0.1 ng/μg of protein (<1EU/μg).
Molecular Weight 11.3 kDa
Formulation Sterile filtered through a 0.2 micron filter. Lyophilized from 5 mM Sodium phosphate, pH 7.0.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Protein Type Recombinant
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