>95% Pure active Human Recombinant Activin B.
Determined by its ability to inhibit the proliferation of mouse MPC-11 cells.
The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥5 x 105 units/mg.
Activin B is a TGF-β family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.