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Human CellExp™ IL-6 Rα, Human Recombinant, BioVision

Supplier: BioVision
7102-10 7102-50
>98% Pure active Human Recombinant Human cell expressed IL-6 Rα.

Determined by its ability to intensify the IL-6 induced growth inhibition of mouse M1 cells. The expected ED50 is ≤ 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.

IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6Rα and gp130. The IL-6Rα chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6Rα. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6Rα alone. IL-6Rα is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6Rα which consists of only the extracellular domain of the IL-6Rα chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6Rα is a 37.6 kDa protein consisting of the extracellular domain of the IL-6Rα chain (339 amino acid residues).




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 μg 7102-10 10009-068 Each (10µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

50 μg 7102-50 10009-070 Each (50µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Protein/Peptide Name IL6 Receptor
Protein Synonyms B cell stimulatory factor-2, CD126, soluble IL-6 receptor alpha
Protein/Peptide Type Recombinant
Species Human
Source HEK293 cells
Purity ≥98%
Endotoxin Content < 0.1 ng/μg of protein (<1EU/μg).
Molecular Weight ~37.6 kDa
Formulation Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS pH 7.2.
Reconstitution Instructions Reconstitute in 1x PBS, pH 7.2 to a concentration of 0.1-1.0 mg/ml. Do not vortex.
Protein Type Recombinant
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