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Human CellExp™ IL-4 Rα, Human Recombinant, BioVision

Supplier: BioVision
7101-50 7101-10
>98% Pure active Human Recombinant Human cell expressed IL-4 Rα.

Determined by its ability to inhibit the IL-4-dependent proliferation of human TF-1 cells. The expected ED50 is ≤ 5.0 ng/ml (in the presence of 0.5 ng/ml of hIL-4), corresponding to a specific activity of ≥ 2 x 105 units/mg.

IL-4 can signal through type I and type II receptor complexes, which share a common gamma chain (γc). The type I receptor contains in addition to the γc an IL-4Rα subunit, whereas the type II receptor contains the IL-13Rα. The secreted extracellular domain of IL-4Rα, called sIL-4Rα, binds IL-4 and antagonizes its activity. It plays an important role in regulating the differentiation of naïve CD4+ T cells and class switching to IgG1 and IgE. Recombinant human sIL-4Rα is a 209 amino acid protein which corresponds to the entire extracellular domain of IL-



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 μg 7101-10 10009-064 Each (10µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

50 μg 7101-50 10009-066 Each (50µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Protein/Peptide Name IL4 Receptor
Protein Synonyms soluble IL-4 receptor alpha
Protein/Peptide Type Recombinant
Species Human
Source HEK293 cells
Purity ≥98%
Endotoxin Content < 0.1 ng/μg of protein (<1EU/μg).
Molecular Weight ~24 kDa
Formulation Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS pH 7.0.
Reconstitution Instructions Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
Protein Type Recombinant
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