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CellExp™ Human Recombinant TNF alpha (from 293 Cells)

CellExp™ Human Recombinant TNF alpha (from 293 Cells)

CellExp™ Human Recombinant TNF alpha (from 293 Cells)

CellExp™

6482-50 6482-10

10008-530EA 630.45 USD

10008-530 10008-528

CellExp™ Human Recombinant TNF alpha (from 293 Cells)

>95% Pure HEK 293 cells expressed Human recombinant TNF-alpha

ED₅₀ is typically < 0.9 ng/mL. The specific activity was determined by the dose-dependent cytotoxity of the TNF alpha sensitive cell line L-929 in the presence of Actinomycin D.

Tumor Necrosis Factor-α (TNF-α) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other target cells. TNF is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.

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