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Human Recombinant NDRG1, BioVision

Supplier: BioVision
>95% Pure Active Recombinant Human NDRG1

The ED50 for this effect is 0.5 - 1.5 ng/ml. Measured in a cell proliferation assay using MCF7 cell.

NDRG1 is a cytoplasmic protein that is involved in stress responses, hormone responses, cell growth, and differentiation. NDRG1 is one of 4 members of the NDRG α/β-hydrolase family. It is classified as a tumor suppressor and heavy metal-response protein. NDRG1’s functions include cell-cycle regulation, cellular differentiation, apoptosis, hypoxia response and metal-ion sensing. It is also essential for p53-mediated caspase activation and apoptosis. NDRG1 is ubiquitous; it is expressed most notably in placental membranes and prostate, kidney, small intestine, and ovary tissues. NDRG1 has reduced expression in adenocarcinomas compared to normal tissues. NDRG1 gene mutations are reported to be the cause for hereditary motor and sensory neuropathy-Lom (HMSNL), which is a severe autosomal recessive form of Charcot- Marie-Tooth (CMT) disease. In addition, decreased NDRG1 expression in glioma is linked to tumor progression. On the other hand, overexpression of NDRG1 is connected to malignant status of esophageal cancer. NDRG1 may also have a role in portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μg 6391-100 10008-504 Each (100µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name NDRG1
Protein Synonyms N-myc downstream regulated 1, GC4, DRG1, CAP43, CMT4D
Protein/Peptide Type Recombinant
Species Human
Source E. coli
Purity ≥95%
Molecular Weight 43.9 kDa
Formulation 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 mM PMSF and 10% glycerol.
Protein Type Recombinant
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