CellExp™ Human Recombinant Noggin (from 293 Cells)

Supplier: BioVision
CellExp™
6474-10 6474-50
10008-714EA 1097.45 USD
10008-714 10008-712
CellExp™ Human Recombinant Noggin (from 293 Cells)
>95% Pure HEK 293 cells expressed Human recombinant Noggin

ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose-dependent inhibition of rhBMP4 induced alkaline phosphate production by ATDC5 cells.

Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.
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