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Human CellExp™ IL-28A, Human Recombinant, BioVision

Supplier: BioVision
>95% Pure HEK 293 cells expressed Human recombinant IL-28A

ED₅₀ is typically 0.5 to 5 ng/mL. The specific activity was determined by the dose-dependent protection of the cytopathic effect on A549 cells (human lung adenocarcinoma epithelial cell line) that were challenged with encephalomyocarditis (EMC) virus.

IL-28A is distantly related to type I interferons and the IL-10 family. Expression of IL-28A is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha. IL-28A exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumor activity. They act similarly to IFNs, but are less effective generally and have activity in a more limited range of cell lines. IL-28A induces ELR (-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. It is able to generate tolerogenic DCs, an activity that could thwart IFN-beta functions. IL-28A produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 µg 6471-10 10008-700 Each (10µG) Retrieving Restricted
50 µg 6471-50 10008-702 Each (50µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name IL28A
Protein Synonyms IFN-Lambda 2, IL28A, ZCYTO20, Interleukin-28A, Interferon-Lambda 2, IL-28A, Cytokine ZCYTO20, IFNL2 Interleukin-28A, IFN-Lambda 2, IL28A, IL-28A, Interferon-Lambda 2, Cytokine ZCYTO20, ZCYTO20, IFNL2
Protein/Peptide Type Recombinant
Species Human
Source 293 cells
Purity > 95%
Endotoxin Content < 1.0 EU per 1 μg of protein
Molecular Weight 24 kDa
Formulation Lyophilized in PBS.
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Protein Type Recombinant
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