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Human CellExp™ IL-17A, Human Recombinant, BioVision

Supplier: BioVision
>95% Pure HEK 293 cells expressed Human recombinant IL-17A

ED₅₀ is typically 5 to 25 ng/mL. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts.

Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappa B and mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 µg 6468-10 10008-688 Each (10µG) Retrieving Restricted
50 µg 6468-50 10008-690 Each (50µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name IL17A
Protein Synonyms CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, IL-17, IL-17A
Protein/Peptide Type Recombinant
Species Human
Source 293 cells
Purity > 95%
Endotoxin Content < 1.0 EU per 1 μg of protein
Molecular Weight 30 to 35 kDa
Formulation Lyophilized in 10 mM Tris, pH 7.4 and 250 mM NaCl.
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Protein Type Recombinant
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