Mouse Recombinant Dhfr (from E. coli)

Supplier: BioVision
AB168723-100UG
10008-488EA 796.72 USD
10008-488
Mouse Recombinant Dhfr (from E. coli)
Proteins and Peptides
>95% Pure Active Recombinant Mouse DHFR

Specific activity is > 0.2 units/mg and was obtained by measuring the oxidation of NADPH in absorbance at 340 nm during reaction.

Dihydrofolate reductase (DHFR) is a member of the reductase family of enzymes that is ubiquitously expressed in all organisms. DHFR catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, and it is essential for the synthesis of thymidylate, purines and several amino acids. Expression of methotrexate (MTX)-resistant variants of DHFR in normal hematopoietic cells is a potential strategy to permit administration of larger doses of MTX by alleviating drug toxicity in normal cells and tissues that are drug sensitive.
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