Human CellExp™ IL-1beta, Human Recombinant, BioVisionSupplier: BioVision
10008-658EA 1364.72 USD10008-658 10008-656
Human CellExp™ IL-1beta, Human Recombinant, BioVision
Proteins and Peptides
>95% Pure HEK 293 cells expressed Human recombinant IL-1beta
ED₅₀ is typically 0.02 to 0.08 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse D10S cells.
Interleukin-1beta is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL1beta proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. In comparison with the E. coli expressed protein, IL-1 beta is 50% more potent in promoting human CD4+ T cell differentiation into Th17 cells. This cytokine is produced in a serumfree, chemically defined media.