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Human Recombinant PAI-1, BioVision

Supplier: BioVision
>95% Pure Active Recombinant Human PAI-1

Specific activity, the IC50 value is < 56 nM. Measured by its ability to inhibit uPA cleavage of the substrate Z-GGR-AMC.

Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator (tPA) and Urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. SERPINE1, however, is the main inhibitor of the plasminogen activators.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μg 6377-100 10008-444 Each (100µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name PAI1
Protein Synonyms Plasminogen activator inhibitor-1, SERPINE1, PAI, PLANH1, PAI1
Protein/Peptide Type Recombinant
Species Human
Source E. coli
Purity ≥95%
Molecular Weight 45 kDa
Formulation 1 mg/ml solution in 150 mM Na2HPO4 (pH 6.6) containing 0.5 mM NaCl, 2 mM Glutathione and 0.01% Tween-80.
Protein Type Recombinant
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