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Human Recombinant FKBP1a/FKBP12, BioVision

Supplier: BioVision
>95% Pure Recombinant Active Human FKBP1a/FKBP12.

Specific activity is > 300 nmoles/min/mg

FKBP1A is part of the family of immunophilins, which have in common high affinity for immunosuppressant drugs and a peptidyl-prolyl cis-trans isomerase (PPIase). In the absence of immunosuppressive ligands, FKBP1A is involved in intracellular calcium regulation by associating with 3 types of Ca2+ release channel complexes: skeletal ryanodine receptors, cardiac ryanodine receptors and the inositol 1, 4, 5-triphosphate receptor. FKBP1A also interacts with TGF type I receptor exerting an inhibitory effect on the TGFβ-I signaling pathway. FKBP12 plays a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. FKBP1A increase the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μg 6340-100 10008-372 Each (100µG) Retrieving Restricted
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SPECIFICATIONS

Protein/Peptide Name Fkbp1A
Protein Synonyms Fkbp12
Protein/Peptide Type Recombinant
Species Human
Source E. coli
Purity ≥95%
Endotoxin Content < 1.0 EU per 1 μg of protein (determined by LAL method).
Molecular Weight 14.1 kDa
Formulation 1 mg/ml solution in 20 mm Tris-HCl buffer (pH 8.0) containing 100 mm NaCl, 1 mm DTT and 10% glycerol.
Protein Type Recombinant
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