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Human Recombinant FKBP1a/FKBP12, BioVision

Supplier: BioVision
>95% Pure Recombinant Active Human FKBP1a/FKBP12.

Specific activity is > 300 nmoles/min/mg

FKBP1A is part of the family of immunophilins, which have in common high affinity for immunosuppressant drugs and a peptidyl-prolyl cis-trans isomerase (PPIase). In the absence of immunosuppressive ligands, FKBP1A is involved in intracellular calcium regulation by associating with 3 types of Ca2+ release channel complexes: skeletal ryanodine receptors, cardiac ryanodine receptors and the inositol 1, 4, 5-triphosphate receptor. FKBP1A also interacts with TGF type I receptor exerting an inhibitory effect on the TGFβ-I signaling pathway. FKBP12 plays a role in modulation of ryanodine receptor isoform-1 (ryr-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. FKBP1A increase the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 μg 6340-100 10008-372 Each (100µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • State issued document with your organization's Federal Tax ID Number
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  • City or County issued Business License
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  • Any other ID issued by the State that includes the business name and address

* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

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Protein/Peptide Name Fkbp1A
Protein Synonyms Fkbp12
Protein/Peptide Type Recombinant
Species Human
Source E. coli
Purity ≥95%
Endotoxin Content < 1.0 EU per 1 μg of protein (determined by LAL method).
Molecular Weight 14.1 kDa
Formulation 1 mg/ml solution in 20 mm Tris-HCl buffer (pH 8.0) containing 100 mm NaCl, 1 mm DTT and 10% glycerol.
Protein Type Recombinant
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