Human Recombinant Granzyme B (from Insect cells)

Supplier: BioVision
4728-5
10007-078EA 438.01 USD
10007-078
Human Recombinant Granzyme B (from Insect cells)
>90% Pure active Recombinant human Granzyme B for studying enzyme regulation, determining target substrates, screening GZMB inhibitors, or as a positive control in GZMB activity assays.

Activity of GZMB was tested using the synthetic peptide, IETD-AFC, as a substrate. GZMB releases AFC and then the GZMB activity can be quantified by fluorescent detection of free AFC at Ex/Em=380/500 nm.

Granzyme B (GZMB) is a serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and assisted by perforin, enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell.
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