Human Recombinant IGFBP1 (from NS0 cells)

Supplier: BioVision
4717-25 4717-100 4717-1000 4717-10
10007-038EA 221.82 USD
10007-038 10007-032 10007-034 10007-036
Human Recombinant IGFBP1 (from NS0 cells)
>98% Pure active Recombinant human IGF-BP1.

The ED₅₀ as determined by its ability to inhibit IGF-I induced proliferation of NUC-1 cells is ~100 ng/ml.

Human IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, decidual, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, whereas nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a single, glycosylated protein consisting of 218 amino acid residues.
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