Human Recombinant Ubiquitin Aldehyde (from E. coli)

Supplier: BioVision
4845-50
10007-196EA 426.14 USD
10007-196
Human Recombinant Ubiquitin Aldehyde (from E. coli)
>95% Pure active Recombinant human Ubiquitin Aldehyde.

The C-terminal glycine carboxyl of Ubiquitin is synthetically modified to an aldehyde. Ubiquitin Aldehyde (Ub-H) is useful in the stabilization of ubiquitin-protein conjugates in vitro, enhancing their accumulation in cell lysates and tissue extracts. Inhibition of deubiquitinylating enzyme activity by Ub-H can be used to identify and confirm such activity and to determine the inhibition kinetics for a particular enzyme. Recommended concentration for maximal inhibition is 2-5 µM. Co-crystallization of ubiquitin aldehyde with specific deubiquitinylating enzymes (the inhibitor mimics the natural ubiquitin substrate) has also been used to probe enzyme:substrate interactions.
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