Caspase-5 Inhibitor Drug Screening Kit, BioVision

Supplier: BioVision
AB102493-100TEST
10013-614EA 1072.52 USD
10013-614
Caspase-5 Inhibitor Drug Screening Kit, BioVision
Assays Protein Assays
Caspases have been shown to play a crucial role in apoptosis induced by various deleterious and physiologic stimuli. Inhibition of caspases can delay apoptosis, implicating a potential role in drug screening efforts. The Caspase-5 Inhibitor Drug Screening Kit provides an effective means for screening caspase inhibitors using fluorometric methods. The assay utilizes synthetic peptide substrate WEHD-AFC (AFC, 7-amino-4-trifluoromethyl coumarin). Active caspase-5 cleaves the synthetic substrate to release free AFC which can then be quantified by fluorometry. Compounds to be screened can directly be added to the reaction and the level of inhibition of caspase-5 activity can be determined by comparison of the fluorescence intensity in samples with and without the testing inhibitors.

  • Fluorescence (Ex/Em 400/505)
  • Mammalian
  • 100 assays
  • Effective means for screening caspase inhibitors using fluorometric methods
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