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IL-21, murine recombinant, BioVision

Supplier: BioVision
4183-1000 4183-10
>95% Pure active Recombinant murine Interleukin-21 (IL-21)

The bioactivity is determined by a dose-dependent proliferation of lymphocytes co-stimulated with anti-CD3ɛ and is typically 2-50 ng/ml.

Mouse Interleukin-21 (m-IL-21), expressed by activated CD4(+) T cells, is the newest member of the common gamma-chain family of cytokines, which also includes IL-2, IL-4, IL-7, IL-9, and IL-13. Its private receptor, IL-21R, is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. IL-21R has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathways upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, the differentiation, and the effector functions of B, T, natural killer, and dendritic cells. Recombinant mouse IL-21, produced in E.coli, is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a total molecular mass of 15,095 Daltons.




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 μg 4183-10 10006-342 Each (10µG) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

1 mg 4183-1000 10006-344 Each (1mg) Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Protein/Peptide Name IL21
Protein Synonyms IL-21, rh-IL-21, IL 21, IL21, h-IL-21 IL21, IL-21, rh-IL-21, h-IL-21, IL 21
Protein/Peptide Type Recombinant
Species Mouse
Source E. coli
Purity ≥95%
Endotoxin Content <0.01 ng/μg
Molecular Weight 15.095 kDa
Formulation Lyophilized from 20 mM NaHCO₃, pH 8.5
Reconstitution Instructions Reconstitute the lyophilized product with sterile H₂O to a concentration of 0.1 mg/ml
Protein Type Recombinant
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