Human Recombinant IL17A (from E. coli)

Supplier: BioVision
4176-1000 4176-25
10006-248EA 3444.11 USD
10006-248 10006-250
Human Recombinant IL17A (from E. coli)
>98% Pure active Recombinant Human Interleukin-17A (IL-17A).

The ED₅₀ as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts is < 2 ng/ml, corresponding to a specific activity of > 5 x 10⁵ units/mg.

The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intraCellular adhesion molecule-1 (ICAM-1) in human fibroblasts. Recombinant IL-17 is a 31 kDa disulfide-linked homodier of two 136 amino acid polypeptide chains.
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