Mouse Recombinant IL4 (from E. coli)

Supplier: BioVision
AB285516-10UG AB285516-1MG AB285516-50UG
10006-140EA 490.3 USD
10006-140 10006-144 10006-142
Mouse Recombinant IL4 (from E. coli)
Proteins and Peptides
A key regulator in humoral and adaptive immunity

The ED₅₀ determined by the dose-dependent stimulation of the proliferation of murine HT-2 cells is <.2.0 ng/ml, corresponding to a specific activity of >5 x 10⁵ units/mg.

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant murine IL-4 is a 13.5 kDa globular protein containing 120 amino acid residues.
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