Human Recombinant Sil-4R (from HEK293 Cells)

Supplier: Tonbo Biosciences
21-7148-U100 21-7148-U015 21-7148-U500 21-7148-U003
10821-132EA 95.93 USD
10821-132 10821-134 10821-136 10821-138
Human Recombinant Sil-4R (from HEK293 Cells)
IL-4R alpha is a Type I transmembrane protein belonging to the class I cytokine receptor family and is a component of two different receptor complexes. When associated with the common gamma chain, which is required for signaling, it binds IL-4 with higher affinity. When complexed with IL-13R alpha I, interaction with both IL-4 and IL-13 is enabled. Through JAK/STAT signal transduction pathways, cell-specific responses including Th2 differentiation, mucosal immunity, allergic inflammation and IgE production result. The soluble form of IL-4R alpha, generated through proteolysis in the human, retains biologic activity and is able to antagonize IL-4.
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