Recombinant Human R-Spondin 3 (Carrier-free), Tonbo BiosciencesSupplier: Tonbo Biosciences
21-7128-U500 21-7128-U005 21-7128-U020 21-7128-U100
10820-922EA 2131.61 USD10820-922 10820-916 10820-918 10820-920
Recombinant Human R-Spondin 3 (Carrier-free), Tonbo Biosciences
Proteins and Peptides
R-Spondin 3 (RSPO3) is a secreted protein belonging to the R-Spondin family of four structurally related Wnt/beta-catenin signaling regulators. All four members contain one thrombospondin-like and two furin-like domains. Studies indicate that R-Spondin 3, prominently expressed in hematopoietic organs, acts as an angiogenic factor during embryogenesis. R-Spondins can enhance Wnt/beta-catenin signaling as they compete with the Wnt agonist DKK-1 for binding to Wnt co-receptors LRP6/Kremen. They can also act as a signaling activation ligand on LRP6 and LGR4 to form a cluster with WNT and FZD. The R-Spondins have been demonstrated to bind to LGR-4, LGR-5 and LGR-6 receptors with high affinity.