Recombinant Human R-Spondin 2 (Carrier-free), Tonbo BiosciencesSupplier: Tonbo Biosciences
21-7127-U500 21-7127-U100 21-7127-U020 21-7127-U005
10820-914EA 2131.61 USD10820-914 10820-912 10820-910 10820-908
Recombinant Human R-Spondin 2 (Carrier-free), Tonbo Biosciences
Proteins and Peptides
R-Spondin 2 (RSPO2) is a secreted protein belonging to the R-Spondin family of four structurally related Wnt/beta-catenin signaling regulators. All four members contain one thrombospondin-like and two furin-like domains. In adults, R-Spondin 2 is expressed in intestine and lung as well as other organs of endodermal origin. R-Spondins can enhance Wnt/beta-catenin signaling as they compete with the Wnt agonist DKK-1 for binding to Wnt co-receptors LRP6/Kremen. They can also act as a signaling activation ligand on LRP6 and LGR4 to form a cluster with WNT and FZD. The R-Spondins have been demonstrated to bind to LGR-4, LGR-5 and LGR-6 receptors with high affinity.