Human Recombinant INSL5/INSL7 (from E. coli)

Supplier: Tonbo Biosciences
21-7110-U005 21-7110-U025 21-7110-U500 21-7110-U100
10820-808EA 221.7 USD
10820-808 10820-806 10820-812 10820-810
Human Recombinant INSL5/INSL7 (from E. coli)
At least seven relaxin-like proteins make up the Insulin/Relaxin superfamily. Most consist of two peptide subunits, an alpha-chain and a beta-chain, linked by disulfide bonds. INSL5 has been identified as the cognate ligand for the G-protein-coupled receptor GPCR142 (RXFP4). INSL7 (Relaxin-3) has been reported as a ligand for LGR7, as well as for GPCR135 and GPCR142. Sequence analysis indicates that INSL5 and INSL7 are highly homologous, but INSL5 seems to be specific only to GPCR142. The recombinant INSL5/INSL7 hybrid protein can activate the G protein coupled receptors GPCR135 and GPCR142, but unlike INSL7, does not induce significant activation of the LGR7 receptor.

  • Carrier-free
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