Human Recombinant Hum (from CHO cells)

Supplier: Tonbo Biosciences
21-7105-U500 21-7105-U050 21-7105-U100 21-7105-U010
10820-752EA 352.91 USD
10820-752 10820-750 10820-754 10820-748
Human Recombinant Hum (from CHO cells)
The Fibroblast Growth Factor Receptor (FGFR) family is made up of four known closely related receptor tyrosine kinases, FGFR1 through 4. For FGFR1 through 3, alternative splicing results in numerous variants. One common splicing event results in the extracellular domain having all 3 immunoglobulin-like domains (alpha isoform) or only the II and III Ig domains (beta isoform). Additional variation in the IgIII domain allows for expression as IIIb or IIIc, again due to alternative splicing. Ligand binding results in dimerization and autophosphorylation of specific tyrosine residues. Variants may exhibit different ligand binding properties. Depending on the isoform, FGFR2 binds FGF-acidic, FGF-basic and keratinocyte growth factor ligands with high affinity.
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