An important growth factor for fibroblasts and endothelial cells.
Recombinant human FGF-4 has full biological activity when compared standards. The ED₅₀, as determined by its ability to induce the proliferation of mouse NR6R-3T3 fibroblasts, is typically 0.25-1.25 ng/ml.
Fibroblast Growth Factor 4 (FGF-4) is a growth factor predominantly expressed during embryonic development, playing a key role in limb development. In culture, FGF-4 has been shown to be an important growth factor for fibroblasts and endothelial cells. Human FGF-4 shares high homology and cross-reactivity with the mouse protein. Recombinant human FGF-4, produced in E.coli, is a non-glycosylated protein containing 177 amino acids and having a total molecular mass of 19 kDa.